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    nhr-23 Nuclear hormone receptor family member nhr-23 [ Caenorhabditis elegans ]

    Gene ID: 172460, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nhr-23
    Official Full Name
    Nuclear hormone receptor family member nhr-23
    Primary source
    WormBase:WBGene00003622
    Locus tag
    CELE_C01H6.5
    See related
    AllianceGenome:WB:WBGene00003622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in chromatin and nucleus. Is expressed in several structures, including gonad; hypodermis; oocyte; spermatocyte; and vulva. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Orthologous to human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nhr-23 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (7214745..7221299)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Flavin-containing monooxygenase Neighboring gene Metal transporter cnnm-4 Neighboring gene Bromo domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An nhr-23::mScarlet::3xMyc knock-in allele for studying spermatogenesis and molting. Myles KM, et al. MicroPubl Biol, 2023. PMID 37854098, Free PMC Article
    2. NHR-23 dependent collagen and hedgehog-related genes required for molting. Kouns NA, et al. Biochem Biophys Res Commun, 2011 Oct 7. PMID 21910973, Free PMC Article
    3. An nhr-85::GFP::AID*::3xFLAG knock-in allele for investigation of molting and oscillatory gene regulation. Myles KM, et al. MicroPubl Biol, 2023. PMID 37927911, Free PMC Article
    4. A spontaneous TIR1 loss-of-function allele in C. elegans. Myles KM, et al. MicroPubl Biol, 2023. PMID 37908494, Free PMC Article
    5. Supplementary nuclear receptor NHR-60 is required for normal embryonic and early larval development of Caenorhabditis elegans. Simecková K, et al. Folia Biol (Praha), 2007. PMID 17579999

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.
      Title: Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.
    2. NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.
      Title: NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.
    3. The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
      Title: The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
    4. these results indicate that NHR-23 is a critical co-regulator of functionally linked genes involved in growth and molting and reveal evolutionary parallels among the ecdysozoa.
      Title: NHR-23 dependent collagen and hedgehog-related genes required for molting.
    5. mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting.
      Title: The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-23
    NP_001020975.1
    • Confirmed by transcript evidence
    NP_001020977.1
    • Confirmed by transcript evidence
    NP_001032969.1
    • Confirmed by transcript evidence
    NP_001032971.1
    • Confirmed by transcript evidence
    NP_001367012.1
    • Confirmed by transcript evidence
    NP_001379448.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7214745..7221299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025806.7 → NP_001020977.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020977.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41828
      Conserved Domains (2) summary
      cd06968
      Location:5 → 99
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:233 → 429
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. NM_001037880.6 → NP_001032969.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001032969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41828
      Conserved Domains (2) summary
      cd06968
      Location:5 → 99
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:235 → 431
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    3. NM_001025804.6 → NP_001020975.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41828, Q17380, Q17584, Q3S1J2, Q3S1J3, Q3S1J4, Q5FC60, Q9BJL3
      Conserved Domains (2) summary
      cd06968
      Location:156 → 250
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:384 → 580
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    4. NM_001380645.2 → NP_001367012.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd06968
      Location:121 → 215
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:349 → 545
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    5. NM_001037882.6 → NP_001032971.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001032971.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41828
      Conserved Domains (2) summary
      cd06968
      Location:121 → 215
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:351 → 547
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    6. NM_001392520.1 → NP_001379448.1  Nuclear hormone receptor family member nhr-23 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cl02596
      Location:1 → 23
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:157 → 353
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41828.2

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