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    lfe-2 Inositol-trisphosphate 3-kinase homolog [ Caenorhabditis elegans ]

    Gene ID: 172128, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lfe-2
    Official Full Name
    Inositol-trisphosphate 3-kinase homolog
    Primary source
    WormBase:WBGene00002979
    Locus tag
    CELE_C46H11.4
    See related
    AllianceGenome:WB:WBGene00002979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A); ITPKB (inositol-trisphosphate 3-kinase B); and ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lfe-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (5027155..5041160)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene PDZ domain-containing protein Neighboring gene putative actin-related protein 2/3 complex subunit 5 Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Computational and molecular characterization of multiple isoforms of lfe-2 gene in nematode C. elegans. Kashyap L, et al. Bioinformation, 2007 May 30. PMID 18084645, Free PMC Article
    2. The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Deng H, et al. Genetics, 2007 Oct. PMID 17720906, Free PMC Article
    3. Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. Kovacevic I, et al. PLoS Genet, 2013 May. PMID 23671426, Free PMC Article
    4. Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis. Yan X, et al. J Gen Physiol, 2006 Oct. PMID 16966474, Free PMC Article
    5. Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Clandinin TR, et al. Cell, 1998 Feb 20. PMID 9491893

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol tetrakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inositol-trisphosphate 3-kinase homolog
    NP_001021047.1
    • Partially confirmed by transcript evidence
    NP_001021048.1
    • Confirmed by transcript evidence
    NP_001021049.1
    • Confirmed by transcript evidence
    NP_001249778.1
    • Partially confirmed by transcript evidence
    NP_001359911.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5027155..5041160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025878.8 → NP_001021049.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q62
      Conserved Domains (1) summary
      pfam03770
      Location:223 → 433
      IPK; Inositol polyphosphate kinase

    2. NM_001262849.3 → NP_001249778.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249778.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q62
      Conserved Domains (1) summary
      pfam03770
      Location:236 → 446
      IPK; Inositol polyphosphate kinase

    3. NM_001372686.1 → NP_001359911.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam03770
      Location:187 → 397
      IPK; Inositol polyphosphate kinase

    4. NM_001025877.6 → NP_001021048.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q62
      Conserved Domains (1) summary
      pfam03770
      Location:156 → 366
      IPK; Inositol polyphosphate kinase

    5. NM_001025876.5 → NP_001021047.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KZ42, H2KZ43, H2KZ45, H2KZ46, H2KZ47, O45049, O45050, O45051, Q95Q62
      Conserved Domains (1) summary
      pfam03770
      Location:256 → 466
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95Q62.1

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