gei-8 Nuclear receptor corepressor 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: gei-8
Gene description: Nuclear receptor corepressor 1
Locus tag: CELE_C14B9.6
See related: AllianceGenome:WB:WBGene00001565
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including anal depressor muscle; egg-laying apparatus; germ line; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to several human genes including NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gei-8 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (8111168..8121232, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans.
Title: GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans.
Knockdown of gei-8, the sole C. elegans NCoR homolog, robustly increased muscle mitochondria and respiration, suggesting evolutionary conservation of NCoR1 function.
Title: NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C14B9.5 (e-PCR)
- UniSTS:308552

C14B9.6 (e-PCR)
- UniSTS:308553

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear receptor corepressor 1

NP_498773.3

Confirmed by transcript evidence

NP_741245.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8111168..8121232 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171207.9 → NP_741245.3 Nuclear receptor corepressor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741245.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P34333

Conserved Domains (3) summary

smart00717
Location:356 → 394

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:356 → 394

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15354
Location:1225 → 1288

KAAG1; Kidney-associated antigen 1
NM_066372.8 → NP_498773.3 Nuclear receptor corepressor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498773.3

Status: REVIEWED

UniProtKB/Swiss-Prot

B5MBV9, P34332, P34333, Q8MYR1

Conserved Domains (3) summary

smart00717
Location:356 → 394

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:356 → 394

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15354
Location:1308 → 1371

KAAG1; Kidney-associated antigen 1