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    clk-2 Telomere length regulation protein clk-2 [ Caenorhabditis elegans ]

    Gene ID: 176065, updated on 18-Sep-2024

    Summary

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    Official Symbol
    clk-2
    Official Full Name
    Telomere length regulation protein clk-2
    Primary source
    WormBase:WBGene00000537
    Locus tag
    CELE_C07H6.6
    See related
    AllianceGenome:WB:WBGene00000537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Hsp90 protein binding activity and telomeric DNA binding activity. Involved in several processes, including DNA damage checkpoint signaling; determination of adult lifespan; and response to X-ray. Located in cytoplasm. Is expressed in several structures, including head ganglion. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See clk-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (7515222..7518524, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene U2 snRNP-associated SURP motif-containing protein Neighboring gene Protein CLASP-1 Neighboring gene RRM domain-containing protein Neighboring gene E3 ubiquitin-protein ligase PPP1R11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway. Guo Y, et al. PLoS One, 2021. PMID 33444416, Free PMC Article
    2. C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Lim CS, et al. Curr Biol, 2001 Oct 30. PMID 11696330
    3. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. Jiang N, et al. J Biol Chem, 2003 Jun 13. PMID 12670948
    4. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Bénard C, et al. Development, 2001 Oct. PMID 11641227
    5. Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. Derry WB, et al. Cell Death Differ, 2007 Apr. PMID 17186023

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway.
      Title: CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway.
    2. Clk-2 mutants accumulate genomic instability and show a delay of embryonic cell cycle timing.
      Title: Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development.
    3. Persistent repair intermediates and/or single-stranded DNA formed during repair of misincorporated uracil are tolerated in the absence of the CLK-2 checkpoint in C. elegans.
      Title: Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates.
    4. DNA damage checkpoint protein clk-2 suppresses the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells.
      Title: Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.
    5. Prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD.
      Title: No reduction of energy metabolism in Clk mutants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Telomere length regulation protein clk-2
    NP_001370399.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7515222..7518524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382917.2 → NP_001370399.1  Telomere length regulation protein clk-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95NL2, Q95YE9
      Conserved Domains (1) summary
      pfam10193
      Location:538 → 645
      Telomere_reg-2; Telomere length regulation protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95YE9.2

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