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    ero-1 Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1 [ Caenorhabditis elegans ]

    Gene ID: 173325, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ero-1
    Official Full Name
    Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1
    Primary source
    WormBase:WBGene00001334
    Locus tag
    CELE_Y105E8B.8
    See related
    AllianceGenome:WB:WBGene00001334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-disulfide reductase activity. Involved in IRE1-mediated unfolded protein response and protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha) and ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ero-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (14664449..14674841)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Hypoxanthine phosphoribosyltransferase Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene Beta-glucuronidase Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Harding HP, et al. Mol Cell, 2003 Mar. PMID 12667446
    2. Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response. Hourihan JM, et al. Mol Cell, 2016 Aug 18. PMID 27540856, Free PMC Article
    3. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Marciniak SJ, et al. Genes Dev, 2004 Dec 15. PMID 15601821, Free PMC Article
    4. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Ye Y, et al. Nature, 2004 Jun 24. PMID 15215856
    5. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Yoneda T, et al. J Cell Sci, 2004 Aug 15. PMID 15280428

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in IRE1-mediated unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1
    NP_001293161.1
    • Confirmed by transcript evidence
    NP_001364626.1
    • Confirmed by transcript evidence
    NP_001364632.1
    • Confirmed by transcript evidence
    NP_001364667.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14664449..14674841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377681.1 → NP_001364626.1  Endoplasmic reticulum oxidoreductin-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YTU4, Q95Q33
      Conserved Domains (1) summary
      pfam04137
      Location:54 → 445
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    2. NM_001377680.2 → NP_001364667.1  Endoplasmic oxidoreductin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FAS8
      Conserved Domains (1) summary
      pfam04137
      Location:54 → 480
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    3. NM_001377682.2 → NP_001364632.1  Endoplasmic reticulum oxidoreductin-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam04137
      Location:2 → 306
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    4. NM_001306232.3 → NP_001293161.1  Endoplasmic reticulum oxidoreductin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLA8
      Conserved Domains (1) summary
      pfam04137
      Location:1 → 217
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YTU4.2

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