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    ncl-1 B box-type domain-containing protein;B-box type zinc finger protein ncl-1;RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 176084, updated on 2-Nov-2024

    Summary

    Official Symbol
    ncl-1
    Official Full Name
    B box-type domain-containing protein;B-box type zinc finger protein ncl-1;RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00003559
    Locus tag
    CELE_ZK112.2
    See related
    AllianceGenome:WB:WBGene00003559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables translation repressor activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of ribosome biogenesis; and nucleologenesis. Located in cytoplasm. Is expressed in several structures, including anal depressor muscle; head; intestine; pharynx; and tail. Orthologous to human TRIM3 (tripartite motif containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ncl-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (7719729..7738105)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene AMP-binding domain-containing protein Neighboring gene Cadherin-3 Neighboring gene ncRNA Neighboring gene Putative serine protease pcp-1

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    B box-type domain-containing protein;B-box type zinc finger protein ncl-1;RING-type E3 ubiquitin transferase
    NP_001299852.1
    • Confirmed by transcript evidence
    NP_001299853.1
    • Confirmed by transcript evidence
    NP_001299924.1
    • Confirmed by transcript evidence
    NP_001299926.1
    • Confirmed by transcript evidence
    NP_001299927.1
    • Confirmed by transcript evidence
    NP_001299928.1
    • Confirmed by transcript evidence
    NP_001368538.1
    • Confirmed by transcript evidence
    NP_001379611.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7719729..7738105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001312923.3NP_001299852.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX41
      Conserved Domains (4) summary
      smart00502
      Location:396522
      BBC; B-Box C-terminal domain
      smart00336
      Location:346389
      BBOX; B-Box-type zinc finger
      cd00162
      Location:87131
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:694964
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    2. NM_001312924.2NP_001299853.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARS2
      Conserved Domains (4) summary
      smart00502
      Location:399525
      BBC; B-Box C-terminal domain
      smart00336
      Location:349392
      BBOX; B-Box-type zinc finger
      cd00162
      Location:87131
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:697967
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    3. NM_001312995.3NP_001299924.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUA6
      Conserved Domains (4) summary
      smart00502
      Location:387513
      BBC; B-Box C-terminal domain
      smart00336
      Location:337380
      BBOX; B-Box-type zinc finger
      cd00162
      Location:75119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:685955
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    4. NM_001379801.1NP_001368538.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARF3
      Conserved Domains (6) summary
      smart00502
      Location:384510
      BBC; B-Box C-terminal domain
      cd14959
      Location:682952
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      TIGR00599
      Location:75181
      rad18; DNA repair protein rad18
      cd19798
      Location:334377
      Bbox2_BRAT-like; B-box-type 2 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
      cd19813
      Location:247290
      Bbox1_BRAT-like; B-box-type 1 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
      cl17238
      Location:75119
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    5. NM_001392143.1NP_001379611.1  B-box type zinc finger protein ncl-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34611
      Conserved Domains (4) summary
      smart00502
      Location:268394
      BBC; B-Box C-terminal domain
      cd14959
      Location:566836
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      cd19798
      Location:218261
      Bbox2_BRAT-like; B-box-type 2 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
      cd19813
      Location:131174
      Bbox1_BRAT-like; B-box-type 1 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
    6. NM_001312997.3NP_001299926.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUY6
      Conserved Domains (4) summary
      smart00502
      Location:333459
      BBC; B-Box C-terminal domain
      smart00336
      Location:283326
      BBOX; B-Box-type zinc finger
      cd00162
      Location:2165
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:631901
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    7. NM_001312998.3NP_001299927.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXB1
      Conserved Domains (4) summary
      smart00502
      Location:330456
      BBC; B-Box C-terminal domain
      smart00336
      Location:280323
      BBOX; B-Box-type zinc finger
      cd00162
      Location:2165
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:628898
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    8. NM_001312999.3NP_001299928.1  B box-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS01
      Conserved Domains (3) summary
      smart00502
      Location:271397
      BBC; B-Box C-terminal domain
      smart00336
      Location:221264
      BBOX; B-Box-type zinc finger
      cd14959
      Location:569839
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins