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    Y48G9A.9 Protein-tyrosine phosphatase [ Caenorhabditis elegans ]

    Gene ID: 175343, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Y48G9A.9
    Official Full Name
    Protein-tyrosine phosphatase
    Primary source
    WormBase:WBGene00021702
    Locus tag
    CELE_Y48G9A.9
    See related
    AllianceGenome:WB:WBGene00021702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in motor neuron axon guidance and signal transduction. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7); PTPRG (protein tyrosine phosphatase receptor type G); and PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Y48G9A.9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (2092709..2099881)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene pseudo Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene PIPK domain-containing protein Neighboring gene CsbD family protein;Late embryogenesis abundant protein D-29-like Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein-tyrosine phosphatase
    NP_001022892.1
    • Confirmed by transcript evidence
    NP_001022893.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2092709..2099881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027721.4 → NP_001022892.1  Protein-tyrosine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ95
      Conserved Domains (2) summary
      smart00194
      Location:62 → 321
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:88 → 321
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001027722.3 → NP_001022893.1  Protein-tyrosine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZG5
      Conserved Domains (2) summary
      smart00194
      Location:71 → 330
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:97 → 330
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version

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