mca-3 Calcium-transporting ATPase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mca-3
Official Full Name: Calcium-transporting ATPase
Primary source: WormBase:WBGene00003153
Locus tag: CELE_Y67D8C.10
See related: AllianceGenome:WB:WBGene00003153
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; positive regulation of endocytosis; and positive regulation of growth rate. Located in plasma membrane. Is expressed in body wall musculature; coelomocyte; intestine; and nervous system. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mca-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 16

Sequence:: Chromosome: IV; NC_003282.8 (3103157..3133149, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data support a function for MCA-3 in the regulation of endocytosis in the C. elegans coelomocytes. In addition, they suggest that endocytosis can be blocked by high calcium levels.
Title: The plasma membrane calcium ATPase MCA-3 is required for clathrin-mediated endocytosis in scavenger cells of Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y67D8A_381.a (e-PCR)
- UniSTS:324473

Y67D8A_367.a (e-PCR)
- UniSTS:323226

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Calcium-transporting ATPase

NP_001255244.1

Partially confirmed by transcript evidence

NP_001294473.1

Partially confirmed by transcript evidence

NP_001370848.1

Confirmed by transcript evidence

NP_001380076.1

Confirmed by transcript evidence

NP_001380077.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3103157..3133149 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392277.1 → NP_001380076.1 Calcium-transporting ATPase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O76832, Q95XP6

Conserved Domains (3) summary

cd02081
Location:55 → 896

P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1

pfam00689
Location:849 → 1026

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam12424
Location:1066 → 1120

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001383061.2 → NP_001370848.1 Calcium-transporting ATPase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O76832, Q8MXS0

Conserved Domains (3) summary

cd02081
Location:55 → 896

P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1

pfam00689
Location:849 → 1026

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam12424
Location:1066 → 1097

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001268315.4 → NP_001255244.1 Calcium-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255244.1

Status: REVIEWED

UniProtKB/TrEMBL

B7CED8, O76832

Conserved Domains (7) summary

cd01427
Location:674 → 815

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

TIGR01517
Location:10 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:166 → 454

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:882 → 1059

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:35 → 98

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12424
Location:1099 → 1124

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

pfam13246
Location:515 → 603

Cation_ATPase; Cation transport ATPase (P-type)
NM_001392278.1 → NP_001380077.1 Calcium-transporting ATPase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O76832, Q95XP5

Conserved Domains (3) summary

cd02081
Location:55 → 896

P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1

pfam00689
Location:849 → 1026

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam12424
Location:1066 → 1108

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001307544.3 → NP_001294473.1 Calcium-transporting ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294473.1

Status: REVIEWED

UniProtKB/TrEMBL

O76832, U4PMD6

Conserved Domains (6) summary

cd01427
Location:434 → 575

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

pfam00122
Location:1 → 214

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:642 → 819

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00702
Location:367 → 570

Hydrolase; haloacid dehalogenase-like hydrolase

pfam12424
Location:859 → 901

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

pfam13246
Location:275 → 363

Cation_ATPase; Cation transport ATPase (P-type)