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    ubc-8 E2 ubiquitin-conjugating enzyme [ Caenorhabditis elegans ]

    Gene ID: 190802, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ubc-8
    Official Full Name
    E2 ubiquitin-conjugating enzyme
    Primary source
    WormBase:WBGene00006705
    Locus tag
    CELE_Y94H6A.6
    See related
    AllianceGenome:WB:WBGene00006705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ubc-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (2704741..2707238, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ATP-dependent RNA helicase;RNA helicase Neighboring gene ncRNA Neighboring gene Ulp1 protease family, C-terminal catalytic domain containing protein Neighboring gene peptidyl-tRNA hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article
    2. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
    3. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    4. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
    5. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E2 ubiquitin-conjugating enzyme
    NP_500245.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2704741..2707238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067844.6 → NP_500245.3  E2 ubiquitin-conjugating enzyme [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N2W9
      Conserved Domains (1) summary
      pfam00179
      Location:15 → 146
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version

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