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    ZC373.5 putative methylthioribulose-1-phosphate dehydratase [ Caenorhabditis elegans ]

    Gene ID: 181218, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZC373.5
    Official Full Name
    putative methylthioribulose-1-phosphate dehydratase
    Primary source
    WormBase:WBGene00013870
    Locus tag
    CELE_ZC373.5
    See related
    AllianceGenome:WB:WBGene00013870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methylthioribulose 1-phosphate dehydratase activity and zinc ion binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be active in cytoplasm. Is expressed in several structures, including head mesodermal cell; hypodermis; intestine; rectal gland cell; and reproductive system. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ZC373.5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (10072209..10074391, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Protein kinase domain-containing protein Neighboring gene Protein dao-4 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylthioribulose 1-phosphate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylthioribulose 1-phosphate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylthioribulose 1-phosphate dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-methionine salvage from S-adenosylmethionine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative methylthioribulose-1-phosphate dehydratase
    NP_509690.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10072209..10074391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077289.7NP_509690.2  putative methylthioribulose-1-phosphate dehydratase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509690.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23261
      Conserved Domains (1) summary
      cl00214
      Location:33232
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...