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    atx-2 Ataxin-2 homolog;Sm domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176465, updated on 2-Nov-2024

    Summary

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    Official Symbol
    atx-2
    Official Full Name
    Ataxin-2 homolog;Sm domain-containing protein
    Primary source
    WormBase:WBGene00000231
    Locus tag
    CELE_D2045.1
    See related
    AllianceGenome:WB:WBGene00000231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in several processes, including microtubule cytoskeleton organization; regulation of cell cycle process; and regulation of gene expression. Located in cytoplasm. Is expressed in body wall musculature; dorsal nerve cord; germ line; gonad; and ventral nerve cord. Used to study autosomal dominant cerebellar ataxia. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2) and ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See atx-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (10461389..10468051)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Protein NLRC3 Neighboring gene ECm29 Proteasome adaptor and Scaffold Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Cullin-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes. Beath EA, et al. Elife, 2024 Jul 30. PMID 39078879, Free PMC Article
    2. The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans. Kiehl TR, et al. J Mol Neurosci, 2000 Dec. PMID 11303786
    3. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4. Gnazzo MM, et al. Mol Biol Cell, 2016 Oct 15. PMID 27559134, Free PMC Article
    4. The Period protein homolog LIN-42 regulates germline development in C. elegans. Berardi S, et al. Mech Dev, 2018 Oct. PMID 30144508
    5. Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Stubenvoll MD, et al. PLoS Genet, 2016 Dec. PMID 28027322, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes.
      Title: Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes.
    2. atx-2 regulates the mechanistic target of rapamycin (mTOR) pathway, downstream of AMP-activated protein kinase (AMPK) and upstream of ribosomal protein S6 kinase and mTOR complex 1 (TORC1), by its direct association with Rab GDP dissociation inhibitor beta.
      Title: Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.
    3. ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins.
      Title: ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of temperature stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in detection of temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of centrosome location IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of centrosome location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to centrosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of female gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fertilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiosis I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of centrosome duplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle, embryonic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic cytokinetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein localization to centrosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of spindle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ataxin-2 homolog;Sm domain-containing protein
    NP_001366696.1
    • Partially confirmed by transcript evidence
    NP_001367113.1
    • Partially confirmed by transcript evidence
    NP_001367186.1
    • Confirmed by transcript evidence
    NP_001367241.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10461389..10468051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379897.1 → NP_001367241.1  Sm domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6K7, G5ED29, Q5FC83
      UniProtKB/TrEMBL
      D4PH96
      Conserved Domains (3) summary
      pfam09606
      Location:626 → 807
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam06741
      Location:283 → 338
      LsmAD; LsmAD domain
      pfam14438
      Location:126 → 198
      SM-ATX; Ataxin 2 SM domain

    2. NM_001379898.1 → NP_001366696.1  Ataxin-2 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6K7, G5ED29, Q5FC83
      Conserved Domains (3) summary
      pfam09606
      Location:518 → 699
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam06741
      Location:175 → 230
      LsmAD; LsmAD domain
      pfam14438
      Location:18 → 90
      SM-ATX; Ataxin 2 SM domain

    3. NM_001379899.1 → NP_001367186.1  Ataxin-2 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6K7, G5ED29, Q5FC83
      Conserved Domains (3) summary
      pfam09606
      Location:518 → 699
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam06741
      Location:175 → 230
      LsmAD; LsmAD domain
      pfam14438
      Location:18 → 90
      SM-ATX; Ataxin 2 SM domain

    4. NM_001379900.3 → NP_001367113.1  Ataxin-2 homolog [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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