otub-1 Ubiquitin thioesterase otubain-like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: otub-1
Official Full Name: Ubiquitin thioesterase otubain-like
Primary source: WormBase:WBGene00007718
Locus tag: CELE_C25D7.8
See related: AllianceGenome:WB:WBGene00007718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Located in plasma membrane. Is expressed in distal tip cell; neuronal sheath cell; neurons; pharynx; and ventral nerve cord. Orthologous to several human genes including OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See otub-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 2

Sequence:: Chromosome: V; NC_003283.11 (15066298..15067352)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

structure of Caenorhabditis elegans OTUB1 bound to human UBC13 at 1.8 A resolution and a 2.35 A resolution quaternary complex structure containing worm OTUB1, Ubal and a UBC13DCA~Ub conjugate generated with Ub(G76C).
Title: The mechanism of OTUB1-mediated inhibition of ubiquitination.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C25D7.9 (e-PCR)
- UniSTS:315597

C25D7.8 (e-PCR)
- UniSTS:321237

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: Ubiquitin thioesterase otubain-like

NP_001369991.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15066298..15067352

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383461.2 → NP_001369991.1 Ubiquitin thioesterase otubain-like [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XVR6

Conserved Domains (1) summary

pfam10275
Location:36 → 273

Peptidase_C65; Peptidase C65 Otubain