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    nuaf-3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [ Caenorhabditis elegans ]

    Gene ID: 187686, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nuaf-3
    Official Full Name
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
    Primary source
    WormBase:WBGene00011123
    Locus tag
    CELE_R07H5.3
    See related
    AllianceGenome:WB:WBGene00011123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nuaf-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (11184291..11186012)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RAP homolog (vertebrate Rap GTPase family) Neighboring gene Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. Chuaijit S, et al. Mitochondrion, 2019 May. PMID 29540318
    2. Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans. van den Ecker D, et al. Mitochondrion, 2012 May. PMID 22387847
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate that two candidates (C50B8.3/NUAF-1, homologue of NDUFAF1 and R07H5.3/NUAF-3, homologue of NDUFAF3) clearly affect complex I function.
      Title: Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
    NP_001023328.1
    • Confirmed by transcript evidence
    NP_001129864.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11184291..11186012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028157.5 → NP_001023328.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93931
      Conserved Domains (1) summary
      cd05125
      Location:72 → 186
      Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...

    2. NM_001136392.4 → NP_001129864.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2MZC3
      Conserved Domains (1) summary
      cd05125
      Location:22 → 136
      Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...
    Nucleotide Protein
    Heading Accession and Version

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