wve-1 WH2 domain-containing protein;Wiskott-Aldrich syndrome protein family member [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wve-1
Official Full Name: WH2 domain-containing protein;Wiskott-Aldrich syndrome protein family member
Primary source: WormBase:WBGene00006958
Locus tag: CELE_R06C1.3
See related: AllianceGenome:WB:WBGene00006958
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in several processes, including generation of neurons; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of SCAR complex. Is expressed in Q cell and anchor cell. Orthologous to human WASF1 (WASP family member 1); WASF2 (WASP family member 2); and WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wve-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (11924541..11929516, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EM studies in adults depleted of branched actin regulators support that WVE-1 maintains established junctions, presumably through its trafficking effect on Cadherin.
Title: WAVE regulates Cadherin junction assembly and turnover during epithelial polarization.
The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.
Title: WAVE binds Ena/VASP for enhanced Arp2/3 complex-based actin assembly.
WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia.
Title: WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia.
UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complex.
Title: UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complex.
results support a model in which the MIG-15 kinase and the UNC-116-WVE-1 complex act on opposite sides of the growth cone to promote robust directional migration
Title: MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1.
in Caenorhabditis elegans, WH2-domain-containing activator of the Arp2/3 complex, WVE-1/WAVE acts redundantly with WSP-1/WASP in axon guidance
Title: The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance.
Animals with impaired wve-1 function display defects in gastrulation, fail to undergo proper morphogenesis, and exhibit defects in neuronal cell migrations and axon outgrowth.
Title: Caenorhabditis elegans WASP and Ena/VASP proteins play compensatory roles in morphogenesis and neuronal cell migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06C1.3 (e-PCR)
- UniSTS:306369

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic ectodermal digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic ectodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of clathrin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WH2 domain-containing protein;Wiskott-Aldrich syndrome protein family member

NP_001251762.1

Confirmed by transcript evidence

NP_001379196.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11924541..11929516 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392954.1 → NP_001379196.1 Wiskott-Aldrich syndrome protein family member [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9XVK6

Conserved Domains (1) summary

cd22057
Location:400 → 422

WH2_WAVE; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family members 1 (WASP1 or WAVE1), 2 (WASP2 or WAVE2) and 3 (WASP3 or WAVE3)
NM_001264833.3 → NP_001251762.1 WH2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251762.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUF0

Conserved Domains (1) summary

smart00246
Location:152 → 169

WH2; Wiskott Aldrich syndrome homology region 2