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    com-1 DNA endonuclease activator Ctp1 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176518, updated on 2-Nov-2024

    Summary

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    Official Symbol
    com-1
    Official Full Name
    DNA endonuclease activator Ctp1 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00008082
    Locus tag
    CELE_C44B9.5
    See related
    AllianceGenome:WB:WBGene00008082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable damaged DNA binding activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See com-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10896363..10901836)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PHD-type domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 Neighboring gene Cuticlin-6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization. Harrell K, et al. Mutat Res, 2021 Jan-Jun. PMID 33975127, Free PMC Article
    2. COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining. Lemmens BB, et al. PLoS Genet, 2013. PMID 23408909, Free PMC Article
    3. NHJ-1 Is Required for Canonical Nonhomologous End Joining in Caenorhabditis elegans. Vujin A, et al. Genetics, 2020 Jul. PMID 32457132, Free PMC Article
    4. Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs. Girard C, et al. Proc Natl Acad Sci U S A, 2018 May 8. PMID 29686104, Free PMC Article
    5. A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination. Penkner A, et al. EMBO J, 2007 Dec 12. PMID 18007596, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our results uncover the potentially lethal properties of NHEJ during meiosis and identify a critical role for COM-1 in NHEJ inhibition and CO assurance in germ cells
      Title: COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing involved in repair via single-strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA endonuclease activator Ctp1 C-terminal domain-containing protein
    NP_499398.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10896363..10901836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066997.4 → NP_499398.3  DNA endonuclease activator Ctp1 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499398.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18606
    Nucleotide Protein
    Heading Accession and Version

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