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    mrpl-40 Large ribosomal subunit protein mL40 [ Caenorhabditis elegans ]

    Gene ID: 175174, updated on 12-Jun-2024

    Summary

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    Gene symbol
    mrpl-40
    Gene description
    Large ribosomal subunit protein mL40
    Locus tag
    CELE_F54C4.1
    See related
    AllianceGenome:WB:WBGene00018793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in mitochondrion and ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Is expressed widely. Used to study chromosome 22q11.2 deletion syndrome, distal. Orthologous to human MRPL40 (mitochondrial ribosomal protein L40). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mrpl-40 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (87559..89243)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene NAM-associated domain-containing protein Neighboring gene Integrin-linked protein kinase homolog pat-4 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Large ribosomal subunit protein mL40
    NP_497138.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      87559..89243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064737.6 → NP_497138.1  Large ribosomal subunit protein mL40 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZ90
      Conserved Domains (1) summary
      pfam09812
      Location:28 → 170
      MRP-L28; Mitochondrial ribosomal protein L28
    Nucleotide Protein
    Heading Accession and Version

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