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    F49E2.5 Nucleolar protein 16;Translation initiation factor IF-2 [ Caenorhabditis elegans ]

    Gene ID: 181175, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F49E2.5
    Official Full Name
    Nucleolar protein 16;Translation initiation factor IF-2
    Primary source
    WormBase:WBGene00009888
    Locus tag
    CELE_F49E2.5
    See related
    AllianceGenome:WB:WBGene00009888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Is expressed in hypodermis; muscle cell; and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See F49E2.5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    22
    Sequence:
    Chromosome: X; NC_003284.9 (9543652..9560804)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Deoxyribonuclease-2 Neighboring gene tRNA-Val Neighboring gene GTP 3',8-cyclase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    2. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleolar protein 16;Translation initiation factor IF-2
    NP_001024694.1
    • Confirmed by transcript evidence
    NP_001024695.1
    • Confirmed by transcript evidence
    NP_001360758.1
    • Confirmed by transcript evidence
    NP_001360760.1
    • Confirmed by transcript evidence
    NP_001360761.1
    • Confirmed by transcript evidence
    NP_001366700.1
    • Confirmed by transcript evidence
    NP_001366701.1
    • Confirmed by transcript evidence
    NP_001366703.1
    • Confirmed by transcript evidence
    NP_001366704.1
    • Confirmed by transcript evidence
    NP_001367019.1
    • Confirmed by transcript evidence
    NP_001367097.1
    • Confirmed by transcript evidence
    NP_001367224.1
    • Confirmed by transcript evidence
    NP_001368747.1
    • Confirmed by transcript evidence
    NP_001368748.1
    • Confirmed by transcript evidence
    NP_001368749.1
    • Confirmed by transcript evidence
    NP_001368750.1
    • Confirmed by transcript evidence
    NP_001368751.1
    • Confirmed by transcript evidence
    NP_001368752.1
    • Confirmed by transcript evidence
    NP_001368753.1
    • Confirmed by transcript evidence
    NP_001368754.1
    • Confirmed by transcript evidence
    NP_001368755.1
    • Confirmed by transcript evidence
    NP_001379062.1
    • Confirmed by transcript evidence
    NP_001379063.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9543652..9560804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029524.6 → NP_001024695.1  Nucleolar protein 16 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q565D1
      Conserved Domains (2) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612
      pfam09420
      Location:1018 → 1072
      Nop16; Ribosome biogenesis protein Nop16

    2. NM_001029523.6 → NP_001024694.1  Nucleolar protein 16 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q565D2
      Conserved Domains (2) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612
      pfam09420
      Location:948 → 1002
      Nop16; Ribosome biogenesis protein Nop16

    3. NM_001373430.3 → NP_001360758.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKJ7
      Conserved Domains (2) summary
      PRK10811
      Location:834 → 996
      rne; ribonuclease E; Reviewed
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612

    4. NM_001392822.1 → NP_001379063.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20626
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612

    5. NM_001373432.4 → NP_001360760.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ILU3
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612

    6. NM_001381054.2 → NP_001368747.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJD5
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612

    7. NM_001381066.1 → NP_001368755.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJF1
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 327
      DUF612; Protein of unknown function, DUF612

    8. NM_001381064.1 → NP_001366704.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20625
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 544
      DUF612; Protein of unknown function, DUF612

    9. NM_001381061.2 → NP_001368751.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INR9
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 614
      DUF612; Protein of unknown function, DUF612

    10. NM_001373433.3 → NP_001360761.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IM76
      Conserved Domains (2) summary
      PRK10811
      Location:579 → 770
      rne; ribonuclease E; Reviewed
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612

    11. NM_001381055.1 → NP_001366703.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45544
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 486
      DUF612; Protein of unknown function, DUF612

    12. NM_001381056.1 → NP_001366700.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45541
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 627
      DUF612; Protein of unknown function, DUF612

    13. NM_001381057.1 → NP_001367097.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6BEV6
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 442
      DUF612; Protein of unknown function, DUF612

    14. NM_001381058.1 → NP_001368748.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKI2
      Conserved Domains (2) summary
      PRK10811
      Location:751 → 913
      rne; ribonuclease E; Reviewed
      pfam04747
      Location:1 → 407
      DUF612; Protein of unknown function, DUF612

    15. NM_001381059.1 → NP_001368749.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKE7
      Conserved Domains (2) summary
      PRK10811
      Location:458 → 657
      rne; ribonuclease E; Reviewed
      pfam04747
      Location:1 → 407
      DUF612; Protein of unknown function, DUF612

    16. NM_001381060.1 → NP_001368750.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKZ1
      Conserved Domains (2) summary
      PRK10811
      Location:566 → 757
      rne; ribonuclease E; Reviewed
      pfam04747
      Location:1 → 592
      DUF612; Protein of unknown function, DUF612

    17. NM_001381062.1 → NP_001368752.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INJ4
      Conserved Domains (2) summary
      PRK10811
      Location:496 → 687
      rne; ribonuclease E; Reviewed
      pfam04747
      Location:1 → 522
      DUF612; Protein of unknown function, DUF612

    18. NM_001381063.1 → NP_001368753.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6M3D2
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 544
      DUF612; Protein of unknown function, DUF612

    19. NM_001381065.1 → NP_001368754.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKK7
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 327
      DUF612; Protein of unknown function, DUF612

    20. NM_001381067.1 → NP_001367224.1  Nucleolar protein 16 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWM5
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 444
      DUF612; Protein of unknown function, DUF612

    21. NM_001392823.1 → NP_001379062.1  Translation initiation factor IF-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45543
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612

    22. NM_001381069.1 → NP_001367019.1  Translation initiation factor IF-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4I3
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 407
      DUF612; Protein of unknown function, DUF612

    23. NM_001381070.1 → NP_001366701.1  Translation initiation factor IF-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45542
      Conserved Domains (1) summary
      pfam04747
      Location:1 → 504
      DUF612; Protein of unknown function, DUF612
    Nucleotide Protein
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