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    ilys-3 Invertebrate-type lysozyme 3 [ Caenorhabditis elegans ]

    Gene ID: 177033, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ilys-3
    Official Full Name
    Invertebrate-type lysozyme 3
    Primary source
    WormBase:WBGene00016670
    Locus tag
    CELE_C45G7.3
    See related
    AllianceGenome:WB:WBGene00016670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables lysozyme activity. Involved in antibacterial innate immune response and defense response to Gram-positive bacterium. Located in late endosome lumen; lysosomal lumen; and recycling endosome lumen. Is expressed in coelomocyte; hypodermis; intestine; and terminal bulb. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ilys-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (2464456..2465443)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cadherin domain-containing protein Neighboring gene Ankyrin repeat protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Invertebrate-type lysozyme 2 Neighboring gene lysozyme

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans. Gravato-Nobre MJ, et al. PLoS Pathog, 2016 Aug. PMID 27525822, Free PMC Article
    2. Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae. Yang WH, et al. Curr Res Microb Sci, 2023. PMID 36798906, Free PMC Article
    3. Physiological and Immunological Regulations in Caenorhabditis elegans Infected with Salmonella enterica serovar Typhi. Sivamaruthi BS, et al. Indian J Microbiol, 2014 Mar. PMID 24426167, Free PMC Article
    4. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
    5. Alterations in Caenorhabditis elegans and Cronobacter sakazakii lipopolysaccharide during interaction. Sivamaruthi BS, et al. Arch Microbiol, 2015 Mar. PMID 25416126

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that C. elegans invertebrate lysozyme ILYS-3 has important roles in both healthy and diseased worms; it is required to enable normal pharyngeal grinder function and to defend against bacterial pathogens
      Title: The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Invertebrate-type lysozyme 3
    NP_500206.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2464456..2465443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067805.5 → NP_500206.1  Invertebrate-type lysozyme 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76357
      Conserved Domains (1) summary
      pfam05497
      Location:17 → 135
      Destabilase; Destabilase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76357.1

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