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    hda-4 Histone deacetylase 4 [ Caenorhabditis elegans ]

    Gene ID: 181723, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hda-4
    Official Full Name
    Histone deacetylase 4
    Primary source
    WormBase:WBGene00001837
    Locus tag
    CELE_C10E2.3
    See related
    AllianceGenome:WB:WBGene00001837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II; receptor guanylyl cyclase signaling pathway; and regulation of neuron differentiation. Located in nucleus. Is expressed in amphid neurons; body wall musculature; motor neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to several human genes including HDAC4 (histone deacetylase 4); HDAC5 (histone deacetylase 5); and HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hda-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (16729559..16744767)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neur_chan_memb domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Inner membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans. Choi KY, et al. Biochem Biophys Res Commun, 2002 May 17. PMID 12054517
    2. A salt-induced kinase is required for the metabolic regulation of sleep. Grubbs JJ, et al. PLoS Biol, 2020 Apr. PMID 32315298, Free PMC Article
    3. The salt-inducible kinase KIN-29 regulates lifespan via the class II histone-deacetylase HDA-4. Nikooei T, et al. MicroPubl Biol, 2020 Aug 9. PMID 33111058, Free PMC Article
    4. Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. Hao Y, et al. PLoS Genet, 2011 May. PMID 21573134, Free PMC Article
    5. Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development. Malinow RA, et al. Sci Rep, 2022 Sep 30. PMID 36180459, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of histone deacetylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Histone deacetylase 4
    NP_001257278.1
    • Confirmed by transcript evidence
    NP_001257279.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16729559..16744767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270349.4 → NP_001257278.1  Histone deacetylase 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257278.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1ZUW2, O17323, Q400M0
      Conserved Domains (1) summary
      cd11681
      Location:460 → 834
      HDAC_classIIa; Histone deacetylases, class IIa

    2. NM_001270350.6 → NP_001257279.1  Histone deacetylase 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17323
      Conserved Domains (1) summary
      cd11681
      Location:407 → 781
      HDAC_classIIa; Histone deacetylases, class IIa
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17323.3

    Gene LinkOut

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