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    • Showing Current items.

    nse-1 Phorbol-ester/DAG-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172295, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nse-1
    Official Full Name
    Phorbol-ester/DAG-type domain-containing protein
    Primary source
    WormBase:WBGene00020843
    Locus tag
    CELE_T27A3.7
    See related
    AllianceGenome:WB:WBGene00020843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nse-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (6107817..6109655, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Molybdopterin synthase catalytic subunit Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene HAP1 N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of NSE-4 Perturbs Genome Stability and DNA Repair in Caenorhabditis elegans. Odiba AS, et al. Int J Mol Sci, 2022 Jun 29. PMID 35806213, Free PMC Article
    2. Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis. Odiba AS, et al. Genetics, 2023 Oct 4. PMID 37579186, Free PMC Article
    3. SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans. Odiba AS, et al. DNA Repair (Amst), 2024 May. PMID 38507953
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phorbol-ester/DAG-type domain-containing protein
    NP_491764.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6107817..6109655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059363.6 → NP_491764.1  Phorbol-ester/DAG-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91501
      Conserved Domains (1) summary
      cl00040
      Location:241 → 275
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    Nucleotide Protein
    Heading Accession and Version

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