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    C11D2.7 PUA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177377, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C11D2.7
    Official Full Name
    PUA domain-containing protein
    Primary source
    WormBase:WBGene00015703
    Locus tag
    CELE_C11D2.7
    See related
    AllianceGenome:WB:WBGene00015703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including MCTS2 (MCTS family member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See C11D2.7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (6154558..6155396, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BLOC-1-related complex subunit 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Queuosine 5'-phosphate N-glycosylase/hydrolase Neighboring gene Ion transport domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PUA domain-containing protein
    NP_741412.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6154558..6155396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171351.4 → NP_741412.1  PUA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXH7
      Conserved Domains (2) summary
      cd11609
      Location:4 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      COG2016
      Location:18 → 177
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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