U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    malt-1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [ Caenorhabditis elegans ]

    Gene ID: 174135, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    malt-1
    Official Full Name
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    Primary source
    WormBase:WBGene00017702
    Locus tag
    CELE_F22D3.6
    See related
    AllianceGenome:WB:WBGene00017702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in RMG and oxygen sensory neurons. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See malt-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (6947855..6951300, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-38;One cut domain family member Neighboring gene Sex-determining transformer protein 2 Neighboring gene Translation initiation factor eIF2B subunit gamma

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article
    2. MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. Vérièpe-Salerno J, et al. Autophagy Rep, 2023 Nov 9. PMID 38510643, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MALT1 has an ancient role modulating neural circuit function downstream of IL-17 to remodel physiology and behavior.
      Title: MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    NP_495424.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6947855..6951300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063023.9 → NP_495424.2  Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495424.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG87
      Conserved Domains (2) summary
      pfam00656
      Location:252 → 481
      Peptidase_C14; Caspase domain
      cl11960
      Location:122 → 182
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools