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    rpn-6.1 putative 26S proteasome regulatory subunit rpn-6.1 [ Caenorhabditis elegans ]

    Gene ID: 175972, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rpn-6.1
    Official Full Name
    putative 26S proteasome regulatory subunit rpn-6.1
    Primary source
    WormBase:WBGene00004462
    Locus tag
    CELE_F57B9.10
    See related
    AllianceGenome:WB:WBGene00004462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable structural molecule activity. Involved in determination of adult lifespan; proteasome assembly; and ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in intestine and pharynx. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rpn-6.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (6959110..6962001, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene CCR4-NOT transcription complex subunit let-711 Neighboring gene Putative pyridoxamine 5'-phosphate oxidase Neighboring gene PAN (PolyA-specific riboNucLease) subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential Thresholds of Proteasome Activation Reveal Two Separable Mechanisms of Sensory Organ Polarization in C. elegans. Kunz P, et al. Front Cell Dev Biol, 2021. PMID 33634121, Free PMC Article
    2. n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease. Fu RH, et al. PLoS One, 2014. PMID 24416384, Free PMC Article
    3. Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis. Ravichandran M, et al. Cell Metab, 2018 Apr 3. PMID 29551589
    4. RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Vilchez D, et al. Nature, 2012 Sep 13. PMID 22922647
    5. UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. MacMorris M, et al. RNA, 2003 Jul. PMID 12810918, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome accessory complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative 26S proteasome regulatory subunit rpn-6.1
    NP_001022621.1
    • Confirmed by transcript evidence
    NP_001022622.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6959110..6962001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027450.5 → NP_001022621.1  putative 26S proteasome regulatory subunit rpn-6.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20938, Q5DX45
      Conserved Domains (2) summary
      COG5159
      Location:19 → 435
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:311 → 405
      PCI; PCI domain

    2. NM_001027451.6 → NP_001022622.1  putative 26S proteasome regulatory subunit rpn-6.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20938
      Conserved Domains (2) summary
      COG5159
      Location:1 → 417
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:293 → 387
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20938.2

    Gene LinkOut

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