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    slo-1 BK channel;Calcium-activated potassium channel slo-1 [ Caenorhabditis elegans ]

    Gene ID: 180203, updated on 12-Jun-2024

    Summary

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    Gene symbol
    slo-1
    Gene description
    BK channel;Calcium-activated potassium channel slo-1
    Locus tag
    CELE_Y51A2D.19
    See related
    AllianceGenome:WB:WBGene00004830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium-activated potassium channel activity and voltage-gated potassium channel activity. Involved in several processes, including behavioral response to ethanol; pharyngeal pumping; and sarcomere organization. Located in M band; striated muscle dense body; and synapse. Is expressed in several structures, including AWC; body wall musculature; non-striated muscle; pharyngeal neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy and alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to several human genes including KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See slo-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    23
    Sequence:
    Chromosome: V; NC_003283.11 (18492261..18508212)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Pept_C1 domain-containing protein Neighboring gene Proton myo-inositol cotransporter hmit-1.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel. Kashyap SS, et al. PLoS Pathog, 2019 Sep. PMID 31553770, Free PMC Article
    2. BK channel clustering is required for normal behavioral alcohol sensitivity in C. elegans. Oh KH, et al. Sci Rep, 2019 Jul 15. PMID 31308408, Free PMC Article
    3. Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. elegans. Li G, et al. Sci Adv, 2019 Jan. PMID 30613772, Free PMC Article
    4. A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo. Scott LL, et al. J Pharmacol Exp Ther, 2018 Nov. PMID 30158242, Free PMC Article
    5. Serotonin Disinhibits a Caenorhabditis elegans Sensory Neuron by Suppressing Ca(2+)-Dependent Negative Feedback. Williams PDE, et al. J Neurosci, 2018 Feb 21. PMID 29358363, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Melatonin promotes sleep by activating the BK channel in C. elegans.
      Title: Melatonin promotes sleep by activating the BK channel in C. elegans.
    2. BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor.
      Title: BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor.
    3. The authors show that ERG-28, an endoplasmic reticulum (ER) membrane protein, promotes the trafficking of SLO-1 BK channels from the ER to the plasma membrane by shielding them from premature degradation.
      Title: ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans.
    4. Enhanced SLO-1 function, via gain-of-function mutation or overexpression, dramatically reduced behavioral impairment during ethanol withdrawal.
      Title: Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in Caenorhabditis elegans.
    5. SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
      Title: SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
    6. SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins, CTN-1 and DYB-1, are crucial for normal SLO-1 cluster formation
      Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
    7. This study demonistrated that the T352I mutation selectively disrupts ethanol modulation of the BK channel.
      Title: Conserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegans.
    8. This study shows cellular and whole organismal behavioral responses to ethanol in C. elegans that directly equate to intoxicating through to supralethal blood alcohol concentrations in humans.
      Title: Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans.
    9. an interaction between BK and EAG family K(+) channels produces the muscle excitability levels that regulate the timing of spicule protraction and the success of male mating behavior.
      Title: Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels.
    10. slo-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
      Title: Ethanol interferes with gustatory plasticity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables large conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BK channel;Calcium-activated potassium channel slo-1
    NP_001024259.1
    • Confirmed by transcript evidence
    NP_001024260.1
    • Confirmed by transcript evidence
    NP_001024261.1
    • Confirmed by transcript evidence
    NP_001256801.1
    • Confirmed by transcript evidence
    NP_001256802.1
    • Confirmed by transcript evidence
    NP_001256803.1
    • Confirmed by transcript evidence
    NP_001256804.1
    • Confirmed by transcript evidence
    NP_001256805.1
    • Confirmed by transcript evidence
    NP_001256806.1
    • Confirmed by transcript evidence
    NP_001256807.1
    • Confirmed by transcript evidence
    NP_001256808.1
    • Confirmed by transcript evidence
    NP_001256809.1
    • Confirmed by transcript evidence
    NP_001256810.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18492261..18508212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269875.4 → NP_001256804.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM4, H7BRM6
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    2. NM_001029090.5 → NP_001024261.1  Calcium-activated potassium channel slo-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM6
      Conserved Domains (3) summary
      pfam00520
      Location:173 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:270 → 355
      Ion_trans_2; Ion channel

    3. NM_001269879.4 → NP_001256808.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM3, H8ESD8
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    4. NM_001029089.3 → NP_001024260.1  Calcium-activated potassium channel slo-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM6
      Conserved Domains (3) summary
      pfam00520
      Location:173 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:270 → 355
      Ion_trans_2; Ion channel

    5. NM_001029088.2 → NP_001024259.1  Calcium-activated potassium channel slo-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95V25, Q95V26, Q95V27, Q9U268
      UniProtKB/TrEMBL
      H7BRM6
      Conserved Domains (3) summary
      pfam00520
      Location:173 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:270 → 355
      Ion_trans_2; Ion channel

    6. NM_001269873.3 → NP_001256802.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRC9, H7BRM3
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    7. NM_001269872.3 → NP_001256801.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM6, H8ESD6
      Conserved Domains (2) summary
      pfam00520
      Location:154 → 375
      Ion_trans; Ion transport protein
      pfam03493
      Location:524 → 599
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    8. NM_001269874.3 → NP_001256803.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM3, H8ESE4
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    9. NM_001269876.3 → NP_001256805.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM6, H8ESE5
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    10. NM_001269877.3 → NP_001256806.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM5, H7BRM6
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    11. NM_001269878.3 → NP_001256807.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM3, H8ESE2
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    12. NM_001269880.3 → NP_001256809.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM6, H8ESE3
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    13. NM_001269881.3 → NP_001256810.1  BK channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H7BRM6, H7BRM7
      Conserved Domains (2) summary
      pfam00520
      Location:139 → 360
      Ion_trans; Ion transport protein
      pfam03493
      Location:509 → 584
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95V25.2

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