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    eif-2A Eukaryotic translation initiation factor 2A [ Caenorhabditis elegans ]

    Gene ID: 174606, updated on 2-Nov-2024

    Summary

    Official Symbol
    eif-2A
    Official Full Name
    Eukaryotic translation initiation factor 2A
    Primary source
    WormBase:WBGene00008480
    Locus tag
    CELE_E04D5.1
    See related
    AllianceGenome:WB:WBGene00008480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleic acid binding activity and ribosome binding activity. Involved in positive regulation of gene expression. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See eif-2A in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (10416800..10419237)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RNase H type-1 domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Eukaryotic translation initiation factor 2A
    NP_001379279.1
    • Confirmed by transcript evidence
    NP_496239.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10416800..10419237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393177.1NP_001379279.1  Eukaryotic translation initiation factor 2A [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_063838.8NP_496239.2  Eukaryotic translation initiation factor 2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496239.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19052, Q95ZW6
      Conserved Domains (3) summary
      pfam08662
      Location:218415
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:280318
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:223394
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...