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    tni-4 Troponin I 4 [ Caenorhabditis elegans ]

    Gene ID: 177295, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tni-4
    Official Full Name
    Troponin I 4
    Primary source
    WormBase:WBGene00006586
    Locus tag
    CELE_W03F8.1
    See related
    AllianceGenome:WB:WBGene00006586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables troponin C binding activity. Involved in embryo development and nematode pharyngeal pumping. Located in sarcomere. Is expressed in pharynx. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to human TNNI1 (troponin I1, slow skeletal type); TNNI2 (troponin I2, fast skeletal type); and TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tni-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (5204591..5207124)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene Solute carrier family 23 member 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
    2. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
    3. Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system. Ono K, et al. Mol Biol Cell, 2004 Jun. PMID 15064356, Free PMC Article
    4. Conservation of mRNA and protein expression during development of C. elegans. Grün D, et al. Cell Rep, 2014 Feb 13. PMID 24462290
    5. Cell-specific proteomic analysis in Caenorhabditis elegans. Yuet KP, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25691744, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables troponin C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Troponin I 4
    NP_500741.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5204591..5207124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068340.7 → NP_500741.2  Troponin I 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500741.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44572, Q5FBV3
      Conserved Domains (1) summary
      pfam00992
      Location:45 → 172
      Troponin; Troponin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44572.2

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