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    gcst-1 Aminomethyltransferase [ Caenorhabditis elegans ]

    Gene ID: 178960, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gcst-1
    Official Full Name
    Aminomethyltransferase
    Primary source
    WormBase:WBGene00017765
    Locus tag
    CELE_F25B4.1
    See related
    AllianceGenome:WB:WBGene00017765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminomethyltransferase activity and transaminase activity. Predicted to be involved in glycine catabolic process. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gcst-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (5712928..5714737)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein pellino Neighboring gene Neuropeptide CCHamide-1 Neighboring gene ncRNA Neighboring gene Rho-GAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article
    2. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aminomethyltransferase
    NP_504502.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5712928..5714737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072101.6 → NP_504502.1  Aminomethyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22968
      Conserved Domains (3) summary
      PLN02319
      Location:2 → 399
      PLN02319; aminomethyltransferase
      pfam01571
      Location:34 → 287
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:297 → 391
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    Nucleotide Protein
    Heading Accession and Version

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