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    cest-1.2 Carboxylic ester hydrolase [ Caenorhabditis elegans ]

    Gene ID: 179914, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cest-1.2
    Official Full Name
    Carboxylic ester hydrolase
    Primary source
    WormBase:WBGene00011364
    Locus tag
    CELE_T02B5.3
    See related
    AllianceGenome:WB:WBGene00011364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cest-1.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (14157663..14160862, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-26 Neighboring gene Carboxylic ester hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Wrobel CJJ, et al. J Am Chem Soc, 2021 Sep 15. PMID 34460264, Free PMC Article
    2. Oligonucleotide Catabolism-Derived Gluconucleosides in Caenorhabditis elegans. Curtis BJ, et al. J Am Chem Soc, 2023 May 31. PMID 37192367, Free PMC Article
    3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Carboxylic ester hydrolase
    NP_506504.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14157663..14160862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074103.7 → NP_506504.2  Carboxylic ester hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506504.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P92016
      Conserved Domains (2) summary
      COG0657
      Location:125 → 250
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:21 → 536
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version

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