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    F26E4.3 putative peptidase C1-like protein F26E4.3 [ Caenorhabditis elegans ]

    Gene ID: 172827, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F26E4.3
    Official Full Name
    putative peptidase C1-like protein F26E4.3
    Primary source
    WormBase:WBGene00009158
    Locus tag
    CELE_F26E4.3
    See related
    AllianceGenome:WB:WBGene00009158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type peptidase activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in proteolysis. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular space and lysosome. Orthologous to several human genes including TINAGL1 (tubulointerstitial nephritis antigen like 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See F26E4.3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (9762403..9767846, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase 2A regulatory subunit sur-6 Neighboring gene Tnp_DDE_dom domain-containing protein Neighboring gene Tyrosine-protein kinase Neighboring gene DNA-directed RNA polymerase III subunit RPC4 Neighboring gene Cytochrome c oxidase polypeptide VIIc

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification. Teuscher AC, et al. Matrix Biol Plus, 2019 Feb. PMID 33543001, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative peptidase C1-like protein F26E4.3
    NP_492593.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9762403..9767846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060192.9 → NP_492593.2  putative peptidase C1-like protein F26E4.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492593.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90850
      Conserved Domains (2) summary
      cd02620
      Location:185 → 428
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam01033
      Location:37 → 82
      Somatomedin_B; Somatomedin B domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90850.3

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