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    sgn-1 Sarcoglycan complex subunit protein [ Caenorhabditis elegans ]

    Gene ID: 184162, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sgn-1
    Official Full Name
    Sarcoglycan complex subunit protein
    Primary source
    WormBase:WBGene00004790
    Locus tag
    CELE_F07H5.2
    See related
    AllianceGenome:WB:WBGene00004790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in sarcomere organization. Predicted to be located in sarcolemma. Predicted to be part of sarcoglycan complex. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2C; autosomal recessive limb-girdle muscular dystrophy type 2F; dilated cardiomyopathy 1L; muscular dystrophy; and type 2 diabetes mellitus. Orthologous to human SGCD (sarcoglycan delta); SGCG (sarcoglycan gamma); and SGCZ (sarcoglycan zeta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sgn-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (8782008..8783670, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phenylalanine-4-hydroxylase Neighboring gene Nematode Specific Peptide family Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 13 Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans. Grisoni K, et al. Gene, 2002 Jul 10. PMID 12234669
    2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in sarcomere organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sarcoglycan complex subunit protein
    NP_495867.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8782008..8783670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063466.5 → NP_495867.1  Sarcoglycan complex subunit protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19185
      Conserved Domains (1) summary
      pfam04790
      Location:77 → 323
      Sarcoglycan_1; Sarcoglycan complex subunit protein
    Nucleotide Protein
    Heading Accession and Version

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