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    T06A4.1 Peptidase M14 carboxypeptidase A domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171669, updated on 2-Nov-2024

    Summary

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    Official Symbol
    T06A4.1
    Official Full Name
    Peptidase M14 carboxypeptidase A domain-containing protein
    Primary source
    WormBase:WBGene00020281
    Locus tag
    CELE_T06A4.1
    See related
    AllianceGenome:WB:WBGene00020281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA6 (carboxypeptidase A6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See T06A4.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (770892..776369)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MiRP K channel accessory Subunit Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M14 carboxypeptidase A domain-containing protein
    NP_001380041.1
    • Confirmed by transcript evidence
    NP_871809.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      770892..776369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182009.5 → NP_871809.1  Peptidase M14 carboxypeptidase A domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0K5
      Conserved Domains (3) summary
      cd03860
      Location:128 → 435
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam01549
      Location:568 → 602
      ShK; ShK domain-like
      pfam02244
      Location:40 → 110
      Propep_M14; Carboxypeptidase activation peptide

    2. NM_001392492.1 → NP_001380041.1  Peptidase M14 carboxypeptidase A domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZH1
      Conserved Domains (1) summary
      cd03860
      Location:1 → 255
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    Nucleotide Protein
    Heading Accession and Version

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