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    W01A11.1 Epoxide hydrolase;Microsomal epoxide hydrolase [ Caenorhabditis elegans ]

    Gene ID: 179036, updated on 12-Jun-2024

    Summary

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    Gene symbol
    W01A11.1
    Gene description
    Epoxide hydrolase;Microsomal epoxide hydrolase
    Locus tag
    CELE_W01A11.1
    See related
    AllianceGenome:WB:WBGene00020909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cis-stilbene-oxide hydrolase activity. Predicted to be involved in aromatic compound catabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including anal sphincter muscle; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See W01A11.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (6499224..6502428)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene Acyltransferase Neighboring gene molybdopterin molybdotransferase Neighboring gene DUF2382 domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-stilbene-oxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ether hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Epoxide hydrolase;Microsomal epoxide hydrolase
    NP_001300208.1
    • Confirmed by transcript evidence
    NP_504650.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6499224..6502428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072249.9 → NP_504650.1  Epoxide hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504650.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23068
      Conserved Domains (3) summary
      COG0596
      Location:122 → 449
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam06441
      Location:51 → 153
      EHN; Epoxide hydrolase N terminus
      cl21494
      Location:126 → 232
      Abhydrolase; alpha/beta hydrolases

    2. NM_001313279.3 → NP_001300208.1  Microsomal epoxide hydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVX4
      Conserved Domains (1) summary
      pfam00561
      Location:1 → 129
      Abhydrolase_1; alpha/beta hydrolase fold
    Nucleotide Protein
    Heading Accession and Version

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