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    dsl-4 Delta-like protein [ Caenorhabditis elegans ]

    Gene ID: 184563, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dsl-4
    Official Full Name
    Delta-like protein
    Primary source
    WormBase:WBGene00001106
    Locus tag
    CELE_F16B12.2
    See related
    AllianceGenome:WB:WBGene00001106
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in cell communication. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dsl-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (14090389..14092054)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene CUB domain-containing protein Neighboring gene Coiled-coil domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A "latent niche" mechanism for tumor initiation. McGovern M, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564624, Free PMC Article
    2. The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Chen N, et al. Dev Cell, 2004 Feb. PMID 14960273
    3. Notch signaling inhibits axon regeneration. El Bejjani R, et al. Neuron, 2012 Jan 26. PMID 22284182, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Delta-like protein
    NP_001359594.1
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14090389..14092054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373566.1 → NP_001359594.1  Delta-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93519
      Conserved Domains (1) summary
      pfam01414
      Location:110 → 166
      DSL; Delta serrate ligand
    Nucleotide Protein
    Heading Accession and Version

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