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    pptr-2 Serine/threonine protein phosphatase 2A regulatory subunit [ Caenorhabditis elegans ]

    Gene ID: 179526, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pptr-2
    Official Full Name
    Serine/threonine protein phosphatase 2A regulatory subunit
    Primary source
    WormBase:WBGene00007554
    Locus tag
    CELE_C13G3.3
    See related
    AllianceGenome:WB:WBGene00007554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein phosphatase activator activity. Involved in P granule assembly. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; reproductive system; and tail. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to several human genes including PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pptr-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (11027153..11030824, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ELYS Neighboring gene Protein quiver Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Heimbucher T, et al. Cell Metab, 2015 Jul 7. PMID 26154057, Free PMC Article
    2. PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos. Kitagawa D, et al. Dev Cell, 2011 Apr 19. PMID 21497765
    3. BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes. Bel Borja L, et al. Elife, 2020 Dec 23. PMID 33355089, Free PMC Article
    4. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Song MH, et al. Dev Cell, 2011 Apr 19. PMID 21497766, Free PMC Article
    5. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Padmanabhan S, et al. Cell, 2009 Mar 6. PMID 19249087, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation.
      Title: Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors.
    2. The PP2A-mediated loading of SAS-6 proteins is critical at the onset of centriole formation.
      Title: PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P granule assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine protein phosphatase 2A regulatory subunit
    NP_001122845.1
    • Confirmed by transcript evidence
    NP_001256283.1
    • Confirmed by transcript evidence
    NP_001369938.1
    • Confirmed by transcript evidence
    NP_001369939.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11027153..11030824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383395.2 → NP_001369938.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17948
      Conserved Domains (1) summary
      pfam01603
      Location:55 → 458
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_001383396.2 → NP_001369939.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3Q1
      Conserved Domains (1) summary
      pfam01603
      Location:59 → 462
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. NM_001129373.4 → NP_001122845.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UJN4
      Conserved Domains (1) summary
      pfam01603
      Location:105 → 508
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. NM_001269354.3 → NP_001256283.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2X3
      Conserved Domains (2) summary
      PLN00122
      Location:380 → 475
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:72 → 475
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein
    Heading Accession and Version

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