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    pod-2 acetyl-CoA carboxylase;biotin carboxylase [ Caenorhabditis elegans ]

    Gene ID: 173500, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pod-2
    Official Full Name
    acetyl-CoA carboxylase;biotin carboxylase
    Primary source
    WormBase:WBGene00004076
    Locus tag
    CELE_W09B6.1
    See related
    AllianceGenome:WB:WBGene00004076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acetyl-CoA carboxylase activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; nematode larval development; and polarity specification of anterior/posterior axis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Is expressed in CAN; excretory duct; hypodermis; intestine; and reproductive system. Used to study muscular disease. Orthologous to several human genes including ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pod-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (1136785..1152701)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene TAF (TBP-associated transcription factor) family;TAF6 C-terminal HEAT repeat domain-containing protein;Transcription initiation factor TFIID subunit 6 Neighboring gene Elongator complex protein 5 Neighboring gene Uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes. Gutbrod P, et al. Sci Rep, 2020 Jul 29. PMID 32728104, Free PMC Article
    2. Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans. Guest M, et al. Pestic Biochem Physiol, 2020 Oct. PMID 32828380
    3. Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo. Tagawa A, et al. Dev Biol, 2001 May 15. PMID 11336504
    4. Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans. Li Y, et al. J Biochem, 2011 May. PMID 21389045
    5. A potential role for fatty acid biosynthesis genes during molting and cuticle formation in Caenorhabditis elegans. Li Y, et al. BMB Rep, 2011 Apr. PMID 21524356

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase;biotin carboxylase
    NP_001022401.1
    • Confirmed by transcript evidence
    NP_001254027.1
    • Confirmed by transcript evidence
    NP_001380055.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1136785..1152701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392999.1 → NP_001380055.1  acetyl-CoA carboxylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GZI3
      Conserved Domains (5) summary
      cd06850
      Location:688 → 754
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:48 → 554
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:606 → 754
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam01039
      Location:1428 → 1965
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:811 → 926
      ACC_central; Acetyl-CoA carboxylase, central region

    2. NM_001267098.3 → NP_001254027.1  acetyl-CoA carboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0M0
      Conserved Domains (8) summary
      cd06850
      Location:799 → 865
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:159 → 665
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:717 → 865
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:159 → 279
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1539 → 2076
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:552 → 659
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:922 → 1037
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:284 → 518
      ATP-grasp_4; ATP-grasp domain

    3. NM_001027230.7 → NP_001022401.1  biotin carboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KQ29
      Conserved Domains (6) summary
      COG0439
      Location:48 → 554
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:606 → 731
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:48 → 168
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02785
      Location:441 → 548
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      cl11404
      Location:688 → 733
      Biotinyl_lipoyl_domains; Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...
      cl17255
      Location:173 → 407
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
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