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    nipi-3 Protein nipi-3 [ Caenorhabditis elegans ]

    Gene ID: 181650, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nipi-3
    Official Full Name
    Protein nipi-3
    Primary source
    WormBase:WBGene00010700
    Locus tag
    CELE_K09A9.1
    See related
    AllianceGenome:WB:WBGene00010700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in defense response to other organism and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including hypodermis; intestine; neurons; pharynx; and spermatheca. Orthologous to human TRIB1 (tribbles pseudokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nipi-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (15607969..15610623)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Equilibrative nucleoside transporter 3 Neighboring gene Ras-related protein Rab-14 Neighboring gene Transcription initiation factor TFIID subunit 5 Neighboring gene Endoplasmic reticulum-Golgi intermediate compartment protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. Kim KW, et al. BMC Biol, 2016 Dec 7. PMID 27927209, Free PMC Article
    2. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. McEwan DL, et al. BMC Biol, 2016 Dec 7. PMID 27927200, Free PMC Article
    3. Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity. Wu C, et al. Cell Rep, 2021 Aug 17. PMID 34407394, Free PMC Article
    4. Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development. Malinow RA, et al. Sci Rep, 2022 Sep 30. PMID 36180459, Free PMC Article
    5. From the outside in and the inside out: Antifungal immune responses in Caenorhabditis elegans. Pukkila-Worley R, et al. Virulence, 2010 May-Jun. PMID 21178428

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
      Title: Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
    2. NIPI-3 negatively controls PMK-1/p38 signalling via transcriptional repression of the C/EBP transcription factor CEBP-1.
      Title: Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development.
    3. NIPI-3 is a negative regulator of CEBP-1, which in turn negatively regulates protective immune mechanisms.
      Title: Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antifungal innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein nipi-3
    NP_510573.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15607969..15610623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078172.10 → NP_510573.3  Protein nipi-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510573.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EED4
      Conserved Domains (1) summary
      cl21453
      Location:208 → 459
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EED4.1

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