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    gck-1 Germinal center kinase 1;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 179274, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gck-1
    Official Full Name
    Germinal center kinase 1;non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00001526
    Locus tag
    CELE_T19A5.2
    See related
    AllianceGenome:WB:WBGene00001526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mitogen-activated protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of endocytic recycling; and regulation of oocyte development. Located in cytoplasm and cytoplasmic side of apical plasma membrane. Used to study cerebral cavernous malformation. Orthologous to several human genes including STK26 (serine/threonine kinase 26). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gck-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (8947799..8956296)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TPR_REGION domain-containing protein Neighboring gene Nuclear hormone receptor family member nhr-44 Neighboring gene Nuclear Hormone Receptor family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel cytokinetic ring components drive negative feedback in cortical contractility. Bell KR, et al. Mol Biol Cell, 2020 Jul 15. PMID 32491957, Free PMC Article
    2. The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. Schouest KR, et al. PLoS One, 2009 Oct 14. PMID 19826475, Free PMC Article
    3. The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. Gruneberg U, et al. J Cell Biol, 2002 Sep 2. PMID 12213836, Free PMC Article
    4. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393
    5. STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo. Lu T, et al. Genetics, 2022 May 5. PMID 35298637, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GCK-1 works together with CCM-3, a known binding partner, to promote intercellular bridge stability and limit localization of both canonical anillin and non-muscle myosin II (NMM-II) to intercellular bridges
      Title: A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges.
    2. GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline
      Title: The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial tube morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Germinal center kinase 1;non-specific serine/threonine protein kinase
    NP_001024141.1
    • Confirmed by transcript evidence
    NP_001300197.1
    • Confirmed by transcript evidence
    NP_001300198.1
    • Confirmed by transcript evidence
    NP_001300199.1
    • Confirmed by transcript evidence
    NP_001300200.1
    • Confirmed by transcript evidence
    NP_001379995.1
    • Confirmed by transcript evidence
    NP_505310.2
    • Confirmed by transcript evidence
    NP_505311.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8947799..8956296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392572.1 → NP_001379995.1  Germinal center kinase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L099, H2L0A0, H2L0A1, Q6ABW4
      Conserved Domains (1) summary
      cd06609
      Location:33 → 305
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    2. NM_001313269.3 → NP_001300198.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVW5
      Conserved Domains (1) summary
      cd06609
      Location:33 → 304
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    3. NM_072910.8 → NP_505311.3  Germinal center kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505311.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L099
      Conserved Domains (2) summary
      smart00220
      Location:184 → 434
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:183 → 454
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    4. NM_072909.5 → NP_505310.2  Germinal center kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505310.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L099
      Conserved Domains (2) summary
      smart00220
      Location:184 → 435
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:183 → 455
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    5. NM_001313270.4 → NP_001300199.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AY55
      Conserved Domains (1) summary
      cd06609
      Location:18 → 289
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    6. NM_001028970.3 → NP_001024141.1  Germinal center kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L099
      Conserved Domains (2) summary
      smart00220
      Location:19 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:18 → 290
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    7. NM_001313268.2 → NP_001300197.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASB9
      Conserved Domains (1) summary
      cd06609
      Location:13 → 285
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    8. NM_001313271.4 → NP_001300200.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASW2
      Conserved Domains (1) summary
      cd06609
      Location:13 → 284
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2L099.1

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