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    C23H4.6 AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181384, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C23H4.6
    Official Full Name
    AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00007694
    Locus tag
    CELE_C23H4.6
    See related
    AllianceGenome:WB:WBGene00007694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be located in chromosome. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in several structures, including head mesodermal cell; nervous system; pharynx; rectal gland cell; and reproductive system. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See C23H4.6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (12235606..12240810)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Carboxylic ester hydrolase Neighboring gene Carboxylic ester hydrolase Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Carboxylic ester hydrolase Neighboring gene Carboxylic ester hydrolase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein
    NP_001257189.1
    • Confirmed by transcript evidence
    NP_001257190.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12235606..12240810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270260.4 → NP_001257189.1  RecF/RecN/SMC N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90750, Q93250
      Conserved Domains (1) summary
      COG1196
      Location:70 → 1116
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001270261.4 → NP_001257190.1  AAA_23 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6VQ85
      Conserved Domains (4) summary
      PRK15354
      Location:251 → 398
      PRK15354; type III secretion system protein SsaK; Provisional
      cd03276
      Location:995 → 1086
      ABC_SMC6_euk; ATP-binding cassette domain of eukaryotic SM6 proteins
      COG1196
      Location:20 → 1066
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl21455
      Location:1 → 151
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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