npr-13 G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npr-13
Official Full Name: G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein
Primary source: WormBase:WBGene00013883
Locus tag: CELE_ZC412.1
See related: AllianceGenome:WB:WBGene00013883
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; hypertension; nicotine dependence; and opiate dependence (multiple). Orthologous to several human genes including PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npr-13 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (14852825..14858603, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS5-13 (e-PCR)
- UniSTS:242288

ZC412.1 (e-PCR)
- UniSTS:320429

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein

NP_001294750.1

Confirmed by transcript evidence

NP_506659.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14852825..14858603 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074258.4 → NP_506659.2 G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506659.2

Status: REVIEWED

UniProtKB/TrEMBL

Q23305

Conserved Domains (1) summary

cd15203
Location:32 → 330

7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001307821.3 → NP_001294750.1 G_PROTEIN_RECEP_F1_2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294750.1

Status: REVIEWED

UniProtKB/TrEMBL

M1ZJ67