ZK1307.8 Glucosidase 2 subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ZK1307.8
Official Full Name: Glucosidase 2 subunit beta
Primary source: WormBase:WBGene00014249
Locus tag: CELE_ZK1307.8
See related: AllianceGenome:WB:WBGene00014249
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Involved in PERK-mediated unfolded protein response. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be part of glucosidase II complex. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease 1. Orthologous to human PRKCSH (PRKCSH beta subunit of glucosidase II). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ZK1307.8 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (9624637..9626641)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1307.8 (e-PCR)
- UniSTS:308258

T15H9.1 (e-PCR)
- UniSTS:315000

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in PERK-mediated unfolded protein response	HEP more info	PubMed

Component	Evidence Code	Pubs
part_of glucosidase II complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glucosidase 2 subunit beta

NP_496073.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9624637..9626641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063672.7 → NP_496073.1 Glucosidase 2 subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496073.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC87

Conserved Domains (4) summary

pfam12999
Location:24 → 176

PRKCSH-like; Glucosidase II beta subunit-like

pfam13499
Location:223 → 261

EF-hand_7; EF-hand domain pair

cl06793
Location:361 → 507

PRKCSH; Glucosidase II beta subunit-like protein

cl08302
Location:216 → 257

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...