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    sptl-2 Serine palmitoyltransferase 2 [ Caenorhabditis elegans ]

    Gene ID: 266646, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sptl-2
    Official Full Name
    Serine palmitoyltransferase 2
    Primary source
    WormBase:WBGene00018398
    Locus tag
    CELE_F43H9.2
    See related
    AllianceGenome:WB:WBGene00018398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sptl-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (8017947..8021715)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II subunit rpb-9 Neighboring gene BSD domain-containing protein Neighboring gene Enoyl-CoA hydratase Neighboring gene Polymerase nucleotidyl transferase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
    2. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Zhang H, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926990, Free PMC Article
    3. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine C-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of serine palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine palmitoyltransferase 2
    NP_505064.1
    • Confirmed by transcript evidence
    NP_505065.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8017947..8021715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072663.7 → NP_505064.1  Serine palmitoyltransferase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20375
      Conserved Domains (2) summary
      PLN02483
      Location:103 → 585
      PLN02483; serine palmitoyltransferase
      COG0156
      Location:184 → 562
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

    2. NM_072664.6 → NP_505065.1  Serine palmitoyltransferase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505065.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20375, Q95ZT7
      Conserved Domains (2) summary
      PLN02483
      Location:75 → 557
      PLN02483; serine palmitoyltransferase
      COG0156
      Location:156 → 534
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20375.1

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