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    nuo-5 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 178735, updated on 26-Jun-2024

    Summary

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    Gene symbol
    nuo-5
    Gene description
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    Locus tag
    CELE_Y45G12B.1
    See related
    AllianceGenome:WB:WBGene00021562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See nuo-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (2698972..2706984)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BACK domain-containing protein;BTB domain-containing protein;Kelch-like protein 8 Neighboring gene L-2-hydroxyglutarate dehydrogenase, mitochondrial Neighboring gene Zinc finger protein-like 1 homolog Neighboring gene VWFA domain-containing protein Neighboring gene ncRNA Neighboring gene G protein-coupled receptor;Serpentine Receptor, class T

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. Falk MJ, et al. PLoS One, 2009 Aug 12. PMID 19672299, Free PMC Article
    2. The role of mitochondria in the life of the nematode, Caenorhabditis elegans. Tsang WY, et al. Biochim Biophys Acta, 2003 Jul 14. PMID 12853115
    3. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
    4. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
    5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    NP_503733.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2698972..2706984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071332.7 → NP_503733.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4Y8
      Conserved Domains (5) summary
      PRK09130
      Location:32 → 717
      PRK09130; NADH dehydrogenase subunit G; Validated
      cd02773
      Location:252 → 630
      MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
      pfam09326
      Location:672 → 707
      NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
      pfam10588
      Location:113 → 152
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
      pfam13510
      Location:30 → 106
      Fer2_4; 2Fe-2S iron-sulfur cluster binding domain
    Nucleotide Protein
    Heading Accession and Version

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