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    rars-1 arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic [ Caenorhabditis elegans ]

    Gene ID: 175659, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rars-1
    Official Full Name
    arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic
    Primary source
    WormBase:WBGene00004679
    Locus tag
    CELE_F26F4.10
    See related
    AllianceGenome:WB:WBGene00004679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable arginine-tRNA ligase activity. Involved in determination of adult lifespan; regulation of gene expression; and translation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rars-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (4914096..4917117, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rhomboid-related protein 1 Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene DUF3149 domain-containing protein;Glutaredoxin domain-containing protein Neighboring gene PDZ domain-containing protein Neighboring gene Conserved Edge Expressed protein Neighboring gene putative DNA-directed RNA polymerases I, II, and III subunit RPABC3 Neighboring gene NEDD8-activating enzyme E1 regulatory subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of oxygen consumption in hypoxia protection by translation factor depletion. Scott B, et al. J Exp Biol, 2013 Jun 15. PMID 23531825, Free PMC Article
    2. Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans. Sun CL, et al. Cell Death Differ, 2014 Apr. PMID 24317200, Free PMC Article
    3. Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury. Kaufman DM, et al. Curr Biol, 2015 Aug 17. PMID 26234215, Free PMC Article
    4. Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases. Anderson LL, et al. Science, 2009 Jan 30. PMID 19179530, Free PMC Article
    5. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Rousakis A, et al. Aging Cell, 2013 Oct. PMID 23692540, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic
    NP_001022551.1
    • Confirmed by transcript evidence
    NP_001022552.1
    • Confirmed by transcript evidence
    NP_001379725.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4914096..4917117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027380.8 → NP_001022551.1  putative arginine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022551.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19825
      Conserved Domains (4) summary
      cd00671
      Location:245 → 511
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      smart01016
      Location:132 → 219
      Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
      PLN02286
      Location:133 → 713
      PLN02286; arginine-tRNA ligase
      cl12020
      Location:550 → 713
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    2. NM_001027381.6 → NP_001022552.1  arginine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65ZK0
      Conserved Domains (4) summary
      cd00671
      Location:245 → 511
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      smart01016
      Location:132 → 219
      Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
      PLN02286
      Location:133 → 677
      PLN02286; arginine-tRNA ligase
      cl12020
      Location:550 → 672
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    3. NM_001393333.1 → NP_001379725.1  putative arginine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HU89
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19825.2

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