U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mrp-1 Multidrug resistance-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180409, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mrp-1
    Official Full Name
    Multidrug resistance-associated protein 1
    Primary source
    WormBase:WBGene00003407
    Locus tag
    CELE_F57C12.5
    See related
    AllianceGenome:WB:WBGene00003407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in dauer larval development; regulatory ncRNA-mediated post-transcriptional gene silencing; and stress response to metal ion. Located in plasma membrane. Is expressed in several structures, including intestine; pharyngeal-intestinal valve; rectal valve cell; seam cell; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mrp-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    23
    Sequence:
    Chromosome: X; NC_003284.9 (576318..587495, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc metalloproteinase nas-38 Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene Bromo domain-containing protein Neighboring gene Neuropeptide-Like Protein;Peptidase_M13 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of ABC transporters acting in vitamin B(12) metabolism in Caenorhabditis elegans. McDonald MK, et al. Mol Genet Metab, 2017 Dec. PMID 29153845
    2. Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans. Saharia K, et al. J Biosci, 2016 Dec. PMID 27966489
    3. Detoxification and sensing mechanisms are of similar importance for Cd resistance in Caenorhabditis elegans. Winter SA, et al. Heliyon, 2016 Oct. PMID 27822562, Free PMC Article
    4. PMK-1 p38 MAPK promotes cadmium stress resistance, the expression of SKN-1/Nrf and DAF-16 target genes, and protein biosynthesis in Caenorhabditis elegans. Keshet A, et al. Mol Genet Genomics, 2017 Dec. PMID 28766017, Free PMC Article
    5. An automated system for measuring parameters of nematode sinusoidal movement. Cronin CJ, et al. BMC Genet, 2005 Feb 7. PMID 15698479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRP-1, through its export activity, supports the induction of the normal life cycle by the insulin signaling pathway.
      Title: Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress response to metal ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stress response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Multidrug resistance-associated protein 1
    NP_001024719.2
    • Confirmed by transcript evidence
    NP_001033553.1
    • Confirmed by transcript evidence
    NP_508122.2
    • Confirmed by transcript evidence
    NP_741702.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      576318..587495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171938.8 → NP_741702.1  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5KQS9, Q8MQ16
      Conserved Domains (5) summary
      TIGR00957
      Location:23 → 1531
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1293 → 1513
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 815
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:976 → 1248
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:309 → 570
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001038464.4 → NP_001033553.1  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3S1M2, Q5KQS9
      Conserved Domains (4) summary
      TIGR00957
      Location:23 → 1531
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1293 → 1513
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 815
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      cl00549
      Location:309 → 570
      ABC_membrane; ABC transporter transmembrane region

    3. NM_001029548.6 → NP_001024719.2  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZW1, Q94136
      Conserved Domains (5) summary
      TIGR00957
      Location:23 → 1531
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1293 → 1513
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 815
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:976 → 1248
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:309 → 570
      ABC_membrane; ABC transporter transmembrane region

    4. NM_075721.10 → NP_508122.2  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508122.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5KQS9, Q95QE2
      Conserved Domains (4) summary
      TIGR00957
      Location:23 → 1531
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1293 → 1513
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 815
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      cl00549
      Location:976 → 1248
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous