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    dhrr-1 G_PROTEIN_RECEP_F2_4 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dhrr-1
    Official Full Name
    G_PROTEIN_RECEP_F2_4 domain-containing protein
    Primary source
    WormBase:WBGene00014035
    Locus tag
    CELE_ZK643.3
    See related
    AllianceGenome:WB:WBGene00014035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in M.vlpaaapp; M.vlpaapaa; M.vrpaaapp; M.vrpaapaa; and head muscle. Human ortholog(s) of this gene implicated in achalasia; isolated growth hormone deficiency; isolated growth hormone deficiency type IB; and obesity. Orthologous to several human genes including ADCYAP1R1 (ADCYAP receptor type I); GLP1R (glucagon like peptide 1 receptor); and GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dhrr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (8944686..8952953)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Arrestin C-terminal-like domain-containing protein;Arrestin domain-containing protein 15 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative deoxycytidylate deaminase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene GRound-Like (grd related)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Family-B G-protein-coupled receptors. Harmar AJ. Genome Biol, 2001. PMID 11790261, Free PMC Article
    2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G_PROTEIN_RECEP_F2_4 domain-containing protein
    NP_001122749.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8944686..8952953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129277.5 → NP_001122749.1  G_PROTEIN_RECEP_F2_4 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30649, P30650
      UniProtKB/TrEMBL
      A7LPE2
      Conserved Domains (2) summary
      smart00008
      Location:142 → 222
      HormR; Domain present in hormone receptors
      cl21561
      Location:230 → 466
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version

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