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    tofu-7 K Homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175988, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tofu-7
    Official Full Name
    K Homology domain-containing protein
    Primary source
    WormBase:WBGene00022737
    Locus tag
    CELE_ZK418.8
    See related
    AllianceGenome:WB:WBGene00022737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA processing and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tofu-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (7083684..7085018, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene K Homology domain-containing protein Neighboring gene NR LBD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis. Goh WS, et al. Genes Dev, 2014 Apr 1. PMID 24696458, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tofu-7 is required for the biogenesis of 21U-RNAs.
      Title: A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    K Homology domain-containing protein
    NP_498547.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7083684..7085018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066146.8 → NP_498547.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23486
      Conserved Domains (2) summary
      smart00322
      Location:59 → 110
      KH; K homology RNA-binding domain
      pfam00013
      Location:165 → 216
      KH_1; KH domain
    Nucleotide Protein
    Heading Accession and Version

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