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    pkc-2 Protein kinase C;Protein kinase C-like 2 [ Caenorhabditis elegans ]

    Gene ID: 181166, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pkc-2
    Official Full Name
    Protein kinase C;Protein kinase C-like 2
    Primary source
    WormBase:WBGene00004033
    Locus tag
    CELE_E01H11.1
    See related
    AllianceGenome:WB:WBGene00004033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium,diacylglycerol-dependent serine/threonine kinase activity and protein serine kinase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cytosol; neuron projection; and neuronal cell body. Is expressed in body wall musculature; intestine; neurons; somatic nervous system; and tail ganglion. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma (multiple); ovarian cancer; and spinocerebellar ataxia type 14. Orthologous to several human genes including PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pkc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (9364818..9386044)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GH84 domain-containing protein Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LisH domain-containing protein Neighboring gene ncRNA Neighboring gene Zinc finger, CCHC-type

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of the Caenorhabditis elegans protein kinase C2 gene. Origins and regulated expression of a family of Ca2+-activated protein kinase C isoforms. Islas-Trejo A, et al. J Biol Chem, 1997 Mar 7. PMID 9045693
    2. A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells. Land M, et al. Mol Cell Biol, 2017 Oct 1. PMID 28716951, Free PMC Article
    3. A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans. Stetak AL, et al. J Neurosci, 2024 Mar 6. PMID 38238075, Free PMC Article
    4. The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans. Sakai N, et al. PLoS One, 2017. PMID 28542414, Free PMC Article
    5. Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. Feng H, et al. J Biol Chem, 2007 Oct 26. PMID 17728253

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
      Title: A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
    2. Results show that PKC-2 is indispensable for thermotaxis behavior. PKC-2 acts in both AFD sensory neurons and intestinal cells to start and sustain cold-directed (cryophilic) migration, which constitutes an early phase of thermotaxis.
      Title: A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells.
    3. data demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specifically by the downstream PKC-2 phosphorylation of UNC-18 on Ser322 in AFD neurons.
      Title: PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase C;Protein kinase C-like 2
    NP_001024516.1
    • Confirmed by transcript evidence
    NP_001024517.1
    • Confirmed by transcript evidence
    NP_001123122.1
    • Confirmed by transcript evidence
    NP_001359883.1
    • Partially confirmed by transcript evidence
    NP_001360727.1
    • Confirmed by transcript evidence
    NP_001360728.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9364818..9386044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129650.6 → NP_001123122.1  Protein kinase C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY36
      Conserved Domains (4) summary
      cd04026
      Location:206 → 336
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:393 → 654
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:396 → 718
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:84 → 136
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_001373417.3 → NP_001360728.1  Protein kinase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKF6
      Conserved Domains (3) summary
      cd04026
      Location:206 → 336
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:396 → 718
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:84 → 134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. NM_001029346.4 → NP_001024517.1  Protein kinase C-like 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90980, P90981, Q19024, Q8MQ87, Q8MQ88
      Conserved Domains (4) summary
      cd04026
      Location:161 → 291
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:348 → 609
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:351 → 673
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:39 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. NM_001029345.6 → NP_001024516.1  Protein kinase C-like 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90980
      Conserved Domains (4) summary
      cd04026
      Location:161 → 291
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:348 → 609
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:351 → 673
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:39 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    5. NM_001373418.2 → NP_001360727.1  Protein kinase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6M3D7
      Conserved Domains (3) summary
      cd04026
      Location:232 → 362
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:422 → 744
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:110 → 160
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    6. NM_001373419.3 → NP_001359883.1  Protein kinase C-like 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd04026
      Location:232 → 362
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:422 → 744
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:110 → 160
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90980.2

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