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    col-19 Cuticle collagen 19 [ Caenorhabditis elegans ]

    Gene ID: 180397, updated on 18-Sep-2024

    Summary

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    Official Symbol
    col-19
    Official Full Name
    Cuticle collagen 19
    Primary source
    WormBase:WBGene00000608
    Locus tag
    CELE_ZK1193.1
    See related
    AllianceGenome:WB:WBGene00000608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in alae of collagen and cuticulin-based cuticle extracellular matrix and annuli extracellular matrix. Is expressed in cuticle; hypodermis; syncytium; vulva; and in male. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See col-19 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_003284.9 (421707..422691)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Late nodulin Neighboring gene VWFA domain-containing protein Neighboring gene tRNA-Gln Neighboring gene Homeobox protein dve-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. Meng F, et al. FEBS J, 2008 Jun. PMID 18479457, Free PMC Article
    2. Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing. Sanzeni A, et al. Elife, 2019 Aug 13. PMID 31407662, Free PMC Article
    3. A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans. Davis MW, et al. Development, 2004 Dec. PMID 15539494
    4. Identification of heterochronic mutants in Caenorhabditis elegans. Temporal misexpression of a collagen::green fluorescent protein fusion gene. Abrahante JE, et al. Genetics, 1998 Jul. PMID 9649524, Free PMC Article
    5. The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans. Rougvie AE, et al. Development, 1995 Aug. PMID 7671813

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of miR-61 and col-19 via TGF-beta and Notch signalling in Caenorhabditis elegans against Klebsiella aerogenes infection.
      Title: Regulation of miR-61 and col-19 via TGF-β and Notch signalling in Caenorhabditis elegans against Klebsiella aerogenes infection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of collagen and cuticulin-based cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cuticle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in alae of collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in annuli extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cuticle collagen 19
    NP_001033577.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      421707..422691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038488.6 → NP_001033577.1  Cuticle collagen 19 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18835, Q23411
      Conserved Domains (2) summary
      pfam01391
      Location:188 → 248
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:4 → 55
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18835.2

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