fer-1 C2 domain-containing protein;Sperm vesicle fusion protein fer-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fer-1
Official Full Name: C2 domain-containing protein;Sperm vesicle fusion protein fer-1
Primary source: WormBase:WBGene00001414
Locus tag: CELE_F43G9.6
See related: AllianceGenome:WB:WBGene00001414
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium-dependent phospholipid binding activity. Involved in several processes, including amoeboid sperm motility; pseudopodium organization; and spermatogenesis. Located in neuronal cell body membrane; organelle membrane; and pseudopodium membrane. Is expressed in body wall muscle cell; spermatid; spermatocyte; and in male. Used to study limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 9; hereditary angioedema; and muscular dystrophy (multiple). Orthologous to several human genes including DYSF (dysferlin) and MYOF (myoferlin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fer-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 21

Sequence:: Chromosome: I; NC_003279.8 (8623012..8631202, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that processes other than sarcomere stability may be affected by loss of fer-1 in C. elegans muscle.
Title: C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered gene expression of muscle enriched genes.
We found three FER-1 isoforms, two of which might arise from FER-1 by proteolysis. By both light and electron microscopy, these FER-1 proteins were found to be localized to membranous organelle membranes.
Title: FER-1 regulates Ca2+ -mediated membrane fusion during C. elegans spermatogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F43G9.6 (e-PCR)
- UniSTS:310305

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in T-tubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in amoeboid sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in pseudopodium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in pseudopodium membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C2 domain-containing protein;Sperm vesicle fusion protein fer-1

NP_001122477.1

Confirmed by transcript evidence

NP_492337.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8623012..8631202 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059936.4 → NP_492337.1 Sperm vesicle fusion protein fer-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17388

Conserved Domains (9) summary

smart00694
Location:859 → 897

DysFC; Dysferlin domain, C-terminal region

cd04017
Location:972 → 1105

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:1384 → 1507

C2E_Ferlin; C2 domain fifth repeat in Ferlin

cd08374
Location:1703 → 1832

C2F_Ferlin; C2 domain sixth repeat in Ferlin

smart00693
Location:734 → 790

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:644 → 718

FerB; FerB (NUC096) domain

pfam08165
Location:548 → 607

FerA; FerA (NUC095) domain

pfam16165
Location:1892 → 2028

Ferlin_C; Ferlin C-terminus

cl14603
Location:284 → 374

C2; C2 domain
NM_001129005.4 → NP_001122477.1 C2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122477.1

Status: REVIEWED

UniProtKB/TrEMBL

B2D6N9

Conserved Domains (9) summary

smart00694
Location:732 → 770

DysFC; Dysferlin domain, C-terminal region

cd04017
Location:845 → 978

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:1257 → 1380

C2E_Ferlin; C2 domain fifth repeat in Ferlin

cd08374
Location:1576 → 1705

C2F_Ferlin; C2 domain sixth repeat in Ferlin

smart00693
Location:607 → 663

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:517 → 591

FerB; FerB (NUC096) domain

pfam08165
Location:421 → 480

FerA; FerA (NUC095) domain

pfam16165
Location:1765 → 1903

Ferlin_C; Ferlin C-terminus

cl14603
Location:157 → 247

C2; C2 domain