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    cpf-1 Cleavage stimulation factor 50 kDa subunit [ Caenorhabditis elegans ]

    Gene ID: 174378, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cpf-1
    Official Full Name
    Cleavage stimulation factor 50 kDa subunit
    Primary source
    WormBase:WBGene00000773
    Locus tag
    CELE_F28C6.3
    See related
    AllianceGenome:WB:WBGene00000773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage stimulating factor complex. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See cpf-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (8600449..8602440, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transcription factor aptf-4 Neighboring gene Transcription factor AP-2 C-terminal domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 2 Neighboring gene Amelotin Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL24 Neighboring gene Suppressor of forked domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extending the CRISPR toolbox for C. elegans: Cpf1 as an alternative gene editing system for AT-rich sequences. Ebbing A, et al. MicroPubl Biol, 2017 Dec 1. PMID 32550354, Free PMC Article
    2. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
    3. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    4. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    5. Functional genomic identification of genes required for male gonadal differentiation in Caenorhabditis elegans. Kalis AK, et al. Genetics, 2010 Jun. PMID 20308279, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage stimulating factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage stimulating factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cleavage stimulation factor 50 kDa subunit
    NP_495822.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8600449..8602440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063421.7 → NP_495822.1  Cleavage stimulation factor 50 kDa subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19864
      Conserved Domains (3) summary
      cd00200
      Location:101 → 421
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:114 → 168
      7WD40; WD40 repeat [structural motif]
      pfam16699
      Location:3 → 60
      CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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